ABSTRACT
OBJECTIVE: We report a retrospective investigation of the prognostic value of bcl-2 and bax expression, and Ki-67 proliferative index in 42 astrocytic tumors. METHODS: We classified the astrocytic tumors and reviewed the clinical information and survival time. The sections were taken from surgically resected paraffin-embedded tissue and performed immunohistochemical stains for bcl-2, bax and Ki-67. RESULTS: The immunohistochemical stain for bcl-2 revealed a positivity in only two(4.76%) among forty-two cases. The immunostain for bax was positive in 35 cases(83.3%). However, the correlation between bcl-2 & bax expression and age, sex, tumor location, size, and histologic grade was not found. By Kaplan-Meier analysis, bcl-2 & bax expression and survival time in astrocytic tumors was no significance in log rank test(p>0.05). There were prognostic values between Ki-67 LI and histologic grade and between Ki-67 LI and survival time, respectively(p<0.05). CONCLUSION: Bcl-2 and bax are not significant, whereas Ki-67 LI is suggested as a significant prognostic factor, associated with histologic grade and survival time of astrocytic tumors.
Subject(s)
Coloring Agents , Kaplan-Meier Estimate , Prognosis , Retrospective StudiesABSTRACT
A 12-years-old female admitted to the hospital with the complaint of pain on the right upper chest area which persisted about 1 month prior to admission. Cafe-au-lait spots of various size laying on a whole body and freckling on the axilla were found on physical examination. A huge mass was found on the plain chest X-ray and on chest MRI. The mass encroached thoracic spine, posterior rib, back muscles, and then into the neural canal and compressed thoracic spinal cord. On the 5th day of hospitalization, the patient complained tingling on the both legs and 2 days later, monoparesis on the right leg. Open thoracotomy and decompressive laminectomy was done to remove mass. Pathologic reports confirmed rhabdomyosarcoma, embryonal type.
Subject(s)
Female , Humans , Axilla , Back Muscles , Cafe-au-Lait Spots , Hospitalization , Laminectomy , Leg , Magnetic Resonance Imaging , Mediastinum , Neural Tube , Paresis , Physical Examination , Rhabdomyosarcoma , Rhabdomyosarcoma, Embryonal , Ribs , Spinal Cord Compression , Spinal Cord , Spine , Thoracotomy , ThoraxABSTRACT
Spontaneous brain stem hemorrhage usually results in higher mortality and morbidity with poorer prognosis than any other intracranial vascular lesions in spite of meticulous medical or surgical treatment. We have experienced 86 cases of spontaneous brain stem hemorrhage who were admitted to Wonju college of medicine from January 1983 to Octobr 1995. 33 cases were treated with operation and 53 cases with non-operative treatment. The results were as follows: 1) Clinical parameters in both operative and non-operative groups showed no significant differences. 2) Treatment results were better in the operative group. Operative treatment is recommended in cases of GCS score below 7, hematoma size larger than 10ml, young age, and normotensive patients. 3) Appropriate operative approaches should be considered according to the patient's status. Recently, we most frequently performed a stereotactic approach. 4) Better outcome was obtained when the patients were operated from 72 hours to one or two weeks following the h emorrhage. 5) Hypertension, old age, and GCS score above 7 showed no statistical differences in terms of outcome between the operative and non-operative groups.
Subject(s)
Humans , Brain Stem , Brain , Hematoma , Hemorrhage , Hypertension , Mortality , PrognosisABSTRACT
We describe a case of metastatic alveolar soft part sarcoma of the brain in a 31 year old women. Alveolar soft part sarcoma is rare tumor that occurs mostly in the extremities and have a high incidence of blood born metastasis. Cerebral metastasis may be the first manifestation of the disease. The histogenesis of alveolar soft part sarcoma remains uncertain. The primary therapeutic option is aggressive surgical excision. Survival even with the development of metasrasis can be long.
Subject(s)
Adult , Female , Humans , Brain , Extremities , Incidence , Neoplasm Metastasis , Sarcoma, Alveolar Soft PartABSTRACT
The clinical analysis of cranial nerve injuries was performed on 435 cases with cranoicrerbral trauma. This prospective study included the correlation between cranial nerve injuries and risk factors such as intracranial hematoma, initial Glasgow Coma Scale(GCS) score, pneumocephalus, and other combined injuries. The results were revealed as follows : 1) 133 cranial nerve injuries(on 97 patients) were noted among 435 craniocerebral trauma victims(97/435=22.2%). 2) The order of frequent cranial nerve injuries was facial nerve(7.3%), olfactory nerve(6.9%), oculomotor nerve(4.4%), abducens nerve(3.9%), optic nerve(3.2%), etc. 3) Bilateral involvment of cranial nerve injuries was noted in 16.5%(22/133). 4) The incidence of immediate onset of cranial nerve injuries was 66.9%(89/133). 5) The incidence of cranial nerve injuries was significantly high in patients with pneumocephalus and low initial GCS score. 6) The functional recovery of injured cranial nerve within 3 months was noted in 30.1%(40/133).
Subject(s)
Humans , Coma , Cranial Nerve Injuries , Cranial Nerves , Craniocerebral Trauma , Hematoma , Incidence , Pneumocephalus , Prospective Studies , Risk FactorsABSTRACT
The causative factors were analyzed clinicostatically on 113 patients who were dead among 1591 head injured patients during recent 3 years from March, 1983. The conclusions are as follows: 1) The mortality ratio of male to female is 2.9 to 1 and especially 3rd to 5th decade is the most prevalent age group(64 cases, 56.6%). 2) The most common mode of injury is motor vehicle accident(71 cases, 62.8%), followed by fall down and struck on the head in the order of frequency. 3) The 60 cases(53.1%) are in the category of lower GCS(Glasgow Coma Scale) score( or = 8) and longer survival time.